PhRMA white paper on ADME pharmacogenomics.
نویسندگان
چکیده
Pharmacogenomic (PGx) research on the absorption, distribution, metabolism, and excretion (ADME) properties of drugs has begun to have impact for both drug development and utilization. To provide a cross-industry perspective on the utility of ADME PGx, the Pharmaceutical Research and Manufacturers of America (PhRMA) conducted a survey of major pharmaceutical companies on their PGx practices and applications during 2003-2005. This white paper summarizes and interprets the results of the survey, highlights the contributions and applications of PGx by industrial scientists as reflected by original research publications, and discusses changes in drug labels that improve drug utilization by inclusion of PGx information. In addition, the paper includes a brief review on the clinically relevant genetic variants of drug-metabolizing enzymes and transporters most relevant to the pharmaceutical industry.
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of America (PhRMA). The design, analysis, and composition of the analyses and manuscript were conducted independently and entirely by the authors, and we are solely responsible for any errors. The authors thank Professor Ernie Berndt of MIT for his review of this paper and several helpful suggestions.
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ورودعنوان ژورنال:
- Journal of clinical pharmacology
دوره 48 7 شماره
صفحات -
تاریخ انتشار 2008